I’m a Biostatistics PhD student at University of Southern California. I am interested in response adaptive designs for randomized controlled trials. My dissertation focuses on:

  • Bayesian covariate-adjusted response adaptive randomization for continuous outcomes
  • Sample size considerations for response adaptive randomized trials
  • Interim decisions for response adaptive randomize trials with sample size re-estimation properties

Before starting my PhD, I worked with neuroimaging data at USC INI. I have graduated from UC Berkeley with BA in Statistics and Applied Mathematics.

Cerebrovascular Reactivity and Mild Cognitive Impairment

 Posted on December 18, 2023  |  Vahan Aslanyan

Very happy that my recent work has been published in Alzheimer’s & Dementia. In this project, we have used data from Systolic Blood Pressure Intervention Trial Memory and Cognition in Decreased Hypertension (SPRINT-MIND) magnetic resonance imaging sub-study to evaluate the association of cerebrovascular reactivity, a measure of brain blood vessel elasticity, with mild cognitive impairment and dementia. We found that cerebrovascular reactivity in AD signature regions is negatively associated with occurrence of mild cognitive impairment, implicating cerebrovascular reactivity in these signature regions as a potential mechanism leading to cognitive impairment. [Read More]